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2-Chloro-1,3,2-dioxaphospholane

Catalog Number
ACM822399-1
Product Name
2-Chloro-1,3,2-dioxaphospholane
Structure
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CAS
822-39-9
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Synonyms
EINECS 212-499-4; 2-Chloro-1,3,2-dioxaphospholane; Ethylene chlorophosphite; AC1Q3VIZ; SC-09222; CTK5E9529; AB1011463; 42280-EP2311829A1; V2040; Ethylene phosphorochloridite(2-chloro-1,3,2-dioxap;
IUPAC Name
2-chloro-1,3,2-dioxaphospholane;
Molecular Weight
126.476g/mol
Molecular Formula
C2H4ClO2P;
Canonical SMILES
C1COP(O1)Cl;
InChI
InChI=1S/C2H4ClO2P/c3-6-4-1-2-5-6/h1-2H2;
InChI Key
OLSFRDLMFAOSIA-UHFFFAOYSA-N;
Storage
2-8°C
Complexity
44.8
Covalently-Bonded Unit Count
1
EC Number
212-499-4
Exact Mass
125.964g/mol
H-Bond Acceptor
2
Heavy Atom Count
6
Monoisotopic Mass
125.964g/mol
Topological Polar Surface Area
18.5A^2
Application
2-Chloro-1,3,2-dioxaphospholane is a clear, colorless oil that serves as a highly reactive cyclic phosphitylating reagent. Its primary purpose is to offer fast coupling rates and easier hydrolytic cleavage compared to acyclic analogs. This makes it an ideal phosphitylating agent in various chemical preparations, such as the synthesis of phosphocholine and spirophosphoranes. For instance, it is effectively utilized in the phosphorylation of p-tert-butyl(thia)calixarenes.
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