Synonyms
BrettPhos Palladacycle
Molecular Weight
798.81
Molecular Formula
C43H63ClNO2PPd
Melting Point
198-204 °C
Purity
97%
Appearance
white to off-white powder or crystals
Symbol
GHS07
NAVIGATION
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- Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II), min. 98% [BrettPhos Palladacycle Gen. 1]
Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II), min. 98% [BrettPhos Palladacycle Gen. 1]
Catalog Number
ACM1148148019-2
Product Name
Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II), min. 98% [BrettPhos Palladacycle Gen. 1]
Structure
![{[CurrentData.Name]}](https://resource.alfachemic.com/structure/1148148-01-9.gif)
CAS
1148148-01-9
Application
Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II), min. 98% [BrettPhos Palladacycle Gen. 1] serves as a highly efficient catalyst designed for a variety of palladium-catalyzed cross-coupling reactions. It excels in C,N-cross coupling of unprotected 3-halo-2-aminopyridines with both primary and secondary amines and facilitates amination reactions and N-arylation of aminophenols. This catalyst is particularly effective for cross-coupling reactions involving aryl mesylates with electron-deficient anilines, enabling rapid C-N bond formation even at low catalyst loadings. Additionally, it supports the cross-coupling of 3-Bromo-2-aminopyridine with primary amines. As a first-generation Buchwald palladacycle precatalyst, this product enhances the formation of various bonds, such as C-C, C-N, C-O, C-F, C-CF3, and C-S, by easily generating the active Pd(0) species through simple base deprotonation. Its high reactivity is maintained even at low temperatures, making it suitable for a wide array of cross-coupling protocols.
February 6, 2025
Efficient Catalyst for Complex Cross-Couplings
I used Alfa Chemistry's BrettPhos Palladacycle Gen. 1 in cross-coupling reactions during our research. It performed exceptionally for C-N bond formation with minimal catalyst loading, simplifying our process and boosting efficiency significantly.
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