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Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct, min. 98% [SPhos Palladacycle Gen. 1]

Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct, min. 98% [SPhos Palladacycle Gen. 1]

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Catalog Number

ACM1028206587-2

Product Name

Structure

CAS

1028206-58-7

Product Overview
Usage

Synonyms

SPhos Palladacycle

Molecular Weight

672.57

Molecular Formula

C34H45ClNO2PPd

Melting Point

160-170 °C

Appearance

white to off-white powder or crystals

MDL Number

MFCD15144765

Symbol

GHS07

Application

Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct, min. 98% [SPhos Palladacycle Gen. 1], serves as an effective catalyst in various chemical reactions. It has been instrumental in the study and development of CDK8/19 inhibitors, helping to discover novel and selective dual inhibitors while addressing the reduction of CYP3A4 time-dependent inhibition. Additionally, this compound plays a critical role in palladium-catalyzed cross-coupling reactions and facilitates C-N bond formation. Its design is influenced by the structure of its ligands, which affects reductive elimination processes in biaryl phosphine-based Pd(II) amido complexes.

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