CAS 1375325-64-6 Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2'-amino-1,1'-biphenyl)]palladium(II)

Molecular Weight

720.62

Molecular Formula

C38H45ClNO2PPd

Purity

Metal purity 99.95

Appearance

white

Color Form

solid

Empirical Formula

Pd(SPhos)[2-(2'-amino-1,1'-biphenyl)]Cl

Metal Content

Application

Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2'-amino-1,1'-biphenyl)]palladium(II) serves as a versatile palladium precatalyst specifically designed for Suzuki-Miyaura coupling reactions. By incorporating a biphenyl-based ligand into its structure, this advanced catalyst efficiently generates the active palladium species at room temperature, even in the presence of weak phosphate or carbonate bases. It excels in facilitating a wide range of cross-coupling reactions, including self-arylation of 1-alkyl-3-bromo-2-phenyl-2,1-borazaronaphthalenes to synthesize 2,1-borazaronaphthols, coupling of [Ru(bpy)2]+ with 4-carboxyphenylboronic acid, and the reaction of β-borylated porphyrins with 2-iodoaniline. These capabilities underscore its significant improvements over previous catalyst generations, enhancing efficiency and broadening the scope of reactions possible in organic synthesis.

March 17, 2025

Essential Catalyst for Efficient Suzuki-Miyaura Couplings

I've used Alfa Chemistry's complex for Suzuki-Miyaura coupling, facilitating effective self-arylation of borazaronaphthalenes in our research. Its efficiency and adaptability at room temperature significantly improved our outcomes. Highly recommend for precise cross-coupling reactions.