Description
Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.
Synonyms
SR-01000076253; D01363; diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum; Carboplatin, British Pharmacopoeia (BP) Reference Standard; MFCD00070464; NSC-241240; CS-1121; NCGC00094961-02; JM-8; SPECTRUM1502106;
IUPAC Name
azane;cyclobutane-1,1-dicarboxylic acid;platinum;
Molecular Weight
373.272g/mol
Molecular Formula
C6H12N2O4Pt;C6H14N2O4Pt;
Canonical SMILES
C1CC(C1)(C(=O)O)C(=O)O.N.N.[Pt];
InChI
InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;;
InChI Key
DVQHYTBCTGYNNN-UHFFFAOYSA-N;
Purity
99.96%
Solubility
Sol in water;Water > 15 (mg/mL);pH 4 Acetate Buffer 5 - 10 (mg/mL);pH 9 Carbonate Buffer 5 - 10 (mg/mL);10% Ethanol/H₂O 5 - 10 (mg/mL);95% Ethanol/H < 1 (mg/mL);0.1NHC1 5 -10 (mg/mL);0.1NNaOH 5 -10 (mg/mL);Methanol < 1 (mg/mL);Chloroform < 5 (mg/mL);Dimethylsulfoxide 5 (mg/mL);Acetic Acid < 1 (mg/mL);Trifluoroacetic Acid < 1 (mg/mL);
Appearance
Solid
Storage
Store at RT
Color Form
White crystals;
Complexity
169
Covalently-Bonded Unit Count
4
Decomposition
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.;
EC Number
255-446-0
Exact Mass
373.06g/mol
H-Bond Acceptor
6
H-Bond Donor
4
Heavy Atom Count
13
Monoisotopic Mass
373.06g/mol
Other Experimental
Incompatible with aluminum;Because of an interaction occurring between carboplatin & the metal aluminum, resulting in precipitate formation & loss of potency, only administration equipment such as needles, syringes, catheters, & sets that contain no aluminum should be used for this drug.;
Stability
The manufacturer states that constituted solns are stable for 8 hr at a room temp not exceeding 25 deg C. However, other information indicates that the drug may be stable for a much longer time. At a concn of 15 mg/ml in sterile water for injection or at concns of 2 & 0.5 mg/ml in dextrose 5% in water, no decomp occurs in 24 hr at 22-25 deg C. Aqueous solns of 10 mg/ml prefilled into plastic syringes exhibited no decomp in 5 days at 4 deg C & only a 3% loss in 24 hr at 37 deg C.;Bulk: No decomposition was detected after 30 days at 60 °C in the dark (HPLC).
Solution: After 48 hours at room temperature an aqueous solution showed < 1% decomposition (HPLC).;
Solution: After 48 hours at room temperature an aqueous solution showed < 1% decomposition (HPLC).;
Topological Polar Surface Area
76.6A^2
