Bis(tri- tert -butylphosphine)palladium(0)

Application

Bis(tri-tert-butylphosphine)palladium(0) serves as a highly versatile catalyst, particularly useful in various cross-coupling reactions vital for organic synthesis. The off-white crystalline solid is specifically employed as a catalyst in Suzuki coupling on multisubstituted sp3-carbon centers, and finds application in Stille, Negishi, and Heck coupling reactions, facilitating the formation of complex organic structures such as tetrasubstituted olefins. Its functionality extends to Buchwald-Hartwig amination of aryl halides, enabling the use of aqueous hydroxide bases, and supports the carbonylation of aryl halides with carbamoylsilanes. Known for its ease of handling, this Pd/P(t-Bu)3-based catalyst simplifies the Negishi cross-coupling of aryl and vinyl chlorides. It further provides significant utility in the cross-coupling of heteroaromatic carboxylic acids, the Pd-catalyzed Newman-Kwart rearrangement of O-aryl thiocarbamates, and the cross-coupling of silanolates and halides. Additionally, it facilitates elimination and isomerization of enol triflates derived from β-ketoesters. The catalyst has undergone enhancements to improve its catalytic efficiency, making it an indispensable tool in the synthesis of complex molecular architectures.