1,1'-Bis(diisopropylphosphino)ferrocene

Application

1,1'-Bis(diisopropylphosphino)ferrocene, an orange crystalline powder, serves as a versatile ligand with a range of catalytic applications. It is particularly effective in facilitating the cross-coupling of thiols with aryl halides when used with Pd(OAc)2, highlighting its utility in palladium-catalyzed reactions. This compound supports numerous transformations, including aminocarbonylation of pyridyl tosylates via ex situ generation of CO, carbonylative α-arylation of ketones with aryl iodides, and alkoxycarbonylation of aryl bromides to synthesize tertiary esters. Its stereoselective decarboxylative allylation and β-C-glycosylation capabilities further demonstrate its role in complex synthesis. Additionally, 1,1'-Bis(diisopropylphosphino)ferrocene is instrumental in ruthenium-catalyzed hydrohydroxyalkylation of 1,1-disubstituted allenes, C-C coupling reactions of fluorinated alcohols with allenes, and cobalt-catalyzed hydroacylation of olefins with N-3-picolin-2-yl aldimines as aldehyde equivalents. The compound's electrochemical behavior follows an ECDim mechanism, and its structural characterization, together with its use in forming complexes such as [MCl2(dippf)] where M can be Pt or Zn, underscores its significance in various chemical applications.