1,1'-Bis(dicyclohexylphosphino)ferrocene

Application

1,1'-Bis(dicyclohexylphosphino)ferrocene is a versatile ligand that plays a crucial role in a range of catalytic processes. It is employed as a ligand in the palladium-catalyzed synthesis of oxindoles through amide α-arylation, enhancing the efficiency and selectivity of this reaction. Additionally, it facilitates the palladium-catalyzed alkoxycarbonylation of aryl chlorides, allowing for effective carbon-carbon bond formation. The product also serves as an essential ligand in ruthenium-catalyzed reactions, specifically in the C-C coupling of alcohols with 1,1-disubstituted allenes via hydrohydroxyalkylation. In nickel-catalyzed systems, it is vital for the cross-coupling of arylboronic acids with aryl carbonates. Furthermore, this ligand supports palladium-catalyzed regiodivergent hydroesterification of aryl olefins with phenyl formate, producing linear phenyl arylpropanoates. Additionally, it facilitates the direct borylation of benzyl alcohol and its analogues in base-free, palladium-catalyzed conditions, showcasing its broad utility across diverse chemical reactions.