2,2'-Bis(diphenylphosphino)-1,1'-biphenyl

Application

2,2'-Bis(diphenylphosphino)-1,1'-biphenyl is a versatile chelating phosphine in the form of a white crystalline powder, utilized extensively in the field of transition metal chemistry. It plays a crucial role as a catalytic ligand in various reactions, notably enhancing the efficiency of Ni- and Pd-catalyzed cross-electrophile coupling for constructing highly substituted 1,3-dienes. Furthermore, it serves as a supporting ligand in chiral diamine-ruthenium systems for the enantioselective hydrogenation of ketones. Its utility extends to palladium-catalyzed amination and Kumada cross-coupling, and it's instrumental in synthesizing butatrenes and chiral allenylsilanes. With iridium, it facilitates C-C cross-coupling through hydrogen transfer reactions involving allenes, dienes, and allylic gem-dicarboxylates with primary alcohols or aldehydes. Additionally, it supports ruthenium-catalyzed syntheses of indoles and oxidative cyclization, along with rhodium-catalyzed boron arylation, showcasing its broad applicability in complex organic synthesis.