[1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(2-isopropoxybenzylidene)ruthenium(II)

Application

[1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(2-isopropoxybenzylidene)ruthenium(II) is a bright green crystalline powder designed as a phosphine-free alternative to the Grubbs 2nd Generation Catalyst, offering comparable reactivity with the added benefit of initiating reactions at lower temperatures. This catalyst is particularly effective for the metathesis of electron-deficient substrates, such as fluorinated olefins, making it valuable for a range of chemical processes. It has been used successfully in several large-scale pharmaceutical applications, facilitating reactions like olefin cross-metathesis with fluorinated olefins (CM), ring-closing metathesis (RCM), and ring-opening metathesis (ROM). Additionally, it supports a sequence of metathesis reactions followed by dihydroxylation of the newly formed double bonds, proving its versatility and efficiency in complex synthetic pathways.