CAS 1375325-71-5 Chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)]palladium(II)

Synonyms

Chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)] palladium(II)

Molecular Weight

512.41

Molecular Formula

C24H37ClNPPd

Melting Point

167-170 °C (dec.)

Purity

0.98

Appearance

off-white to pale yellow powder

MDL Number

MFCD21608496

Application

Chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)]palladium(II) serves as a versatile catalyst in various cross-coupling reactions. This second-generation precatalyst, characterized by its biphenyl-based ligand, is effective for forming carbon-carbon, carbon-nitrogen, and carbon-oxygen bonds. It facilitates reactions such as Suzuki-Miyaura coupling and Stille cross-coupling with aryl halides, including both bromides and chlorides. Additionally, it is active at room temperature when combined with weak phosphate or carbonate bases, making it particularly useful for synthesizing sterically hindered biaryls and compounds like chloropeptin I. Its utility extends to Heck and Negishi cross-coupling reactions, as well as the Suzuki coupling of brominated 2,1-borazaronaphthalenes with potassium organotrifluoroborates, showcasing its broad applicability in complex organic syntheses.

January 10, 2025

Essential Catalyst for Advanced Cross-Coupling Reactions

The Chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)]palladium(II) from Alfa Chemistry was integral to our synthesis of sterically hindered biaryls. It performed exceptionally well in Suzuki and Stille reactions, facilitating efficient C-C bond formations.